Question What can I do to optimize the audio performance on Mac OS X

Answer Please do the following:  Optimize Energy Saver This optimization will free up system resources as well as prevent the computer from going to sleep or standby mode which can cause audio dropouts software and hardware.
  • Click the 'Energy Saver' preferenceSet the slider for 'Put the computer to sleep...' to 'Never'
  • Uncheck the box for 'Put the hard disk(s) to sleep when possible'. 
Turn off Wi-Fi (formerly called AirPort)   If your computer is equipped with Bluetooth wireless and/or a Wi-Fi (AirPort) card, these may need to be disabled to work correctly - freeing up system resources
  • Click the 'Network' preference.
  • On the left hand sidebar, click on Wi-Fi.
  • Click on the button that says Turn Wi-Fi Off. 
Turn off Bluetooth
  • Click on the 'Bluetooth' preference.'
  • Uncheck the box for 'On'. 
Disable FireWire Networking This optimization can help free up bandwidth in the firewire bus
  • Click on the 'Network' preference.
  • On the left hand sidebar, click on FireWire or Built-In FireWire.
  • Click on the drop-down menu for 'Configure IPv4' and choose Off.
  • Click Apply and restart your computer. 
Disable FileVault protection This optimization will allow your hard drive to work more efficiently
  • Click the 'Security & Privacy' preference.
  • Click on the 'FileVault' tab.
  • In this window find where is states: 'FileVault protection is (on/off) for the hard disk...'.
  • If FileVault is on, click the button to 'Turn Off FileVault'. 
Repair Disk Permissions
  • Double-click on the Macintosh HD icon on your desktop. (This would be your system drive if you have renamed it to something else.)
  • Go to the Applications folder.
  • Go to the Utilities folder.
  • Double-click on Disk Utility.
  • Select the boot volume. (This would be called 'Macintosh HD' unless you have renamed it to something else)
  • Go to the 'First Aid' tab and select "Repair Disk Permissions".