Question Is it possible to run the two inputs and outputs simultaneously with separate effects on each side I would like some effects to be in front of the amp, and some other effects to be in the effects loop. The signal chain would be like this: Guitar > G-Major 2 (left side) > AmpAmp FX-loop send > G-Major 2 (right side) > Amp FX-loop return

This is not possible as the G-Major 2 is not a dual-mono device. The 2 channels of the unit cannot be separated and processed independently. They only allow stereo mode and will output a stereo signal. This is also true for the original G-Major and the G-Force.