It is possible to route your interface as an input and output device within Skype or Zoom to transmit audio to and from the software. This will be useful should you want to use a designated microphone or even a line level instrument over Skype/Zoom. However, this is not multi-tracking software. This means you will not be able to use more than one input channel to transmit audio at a time.
Keywords: UM2, UMC22, UMC202HD, UMC204HD, UMC404HD, UMC1820